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目的:利用Meta分析定量评价血管内皮生长因子(vascular endothelial growth factor,VEGF)与亚洲胃癌患者临床病理学特征的关联性。方法:检索PubMed、中国知网(China National Knowledge In frastructure,CNKI)和维普全文期刊数据库中所有已发表胃癌组织中VEGF表达与病理学参数及其预后的相关性研究,应用STATA9.0SE软件进行不同组间VEGF表达比值比(oddratio,OR)和95%可信区间(95%confidence interval,CI)以及文献异质性和偏倚评估。结果:共纳入132篇研究文献;胃癌组织中VEGF的表达显著高于正常胃黏膜组织(P=0.000);且癌组织中VEGF的表达与肿瘤浸润深度(OR=3.32,95%CI=2.82～3.91)、淋巴转移(OR=3.52,95%CI=3.02～4.10)、远处转移(OR=2.88,95%CI=1.94～4.27)、静脉侵犯(OR=2.19,95%CI=1.68～2.85)和TNM分期(OR=3.98,95%CI=3.31～4.78)均有显著相关性。结论:VEGF蛋白可作为预测胃癌浸润转移以及评价患者预后的生物学指标,成为胃癌诊治中较有价值的早期分子标志物。
OBJECTIVE: To quantitatively evaluate the relationship between vascular endothelial growth factor (VEGF) and the clinicopathological features of gastric cancer patients in Asia by Meta-analysis. Methods: The correlation between VEGF expression and pathological parameters and their prognosis in all published gastric cancer tissues in PubMed, China National Knowledge Instiitration (CNKI) and VIP database were searched and analyzed by STATA 9.0SE software The odds ratio (OR) and 95% confidence interval (CI) of VEGF expression in the group and the heterogeneity and bias of the literature were evaluated. Results: A total of 132 studies were included in the literature. The expression of VEGF in gastric cancer was significantly higher than that in normal gastric mucosa (P = 0.000). The expression of VEGF and depth of tumor infiltration (OR = 3.32, 95% CI = 2.82 ~ 3.91), lymph node metastasis (OR = 3.52, 95% CI 3.02-4.10), distant metastasis (OR = 2.88,95% CI = 1.94-4.27) ) And TNM staging (OR = 3.98, 95% CI = 3.31 ~ 4.78). Conclusion: VEGF protein can be used as a biomarker to predict the invasion and metastasis of gastric cancer and to evaluate the prognosis of patients with gastric cancer. It has become a valuable early molecular marker in the diagnosis and treatment of gastric cancer.