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目的:了解子宫内膜异位症并不孕症患者自身免疫抗体指数及其血清内分泌激素状况。方法:抽选汕头大学医学院第二附属医院妇产科2014年11月至2017年2月收治的子宫内膜异位症并不孕患者33例(Ⅰ组)、不孕症患者33例(Ⅱ组)、子宫内膜异位症患者33例(Ⅲ组)以及体检者33例(Ⅳ组),分析其免疫抗体指数、血清内分泌激素状况等。结果:Ⅱ组雌二醇(E2)值(140.00±77.25)ng·mL~(-1),比Ⅰ组、Ⅲ组以及Ⅳ组高,差异具有统计学意义(P<0.05);同时其抗体阳性、催乳素(PRL)值、胰岛素(INS)值以及睾酮(T)值也比Ⅰ组、Ⅲ组以及Ⅳ组高,差异具有统计学意义(P<0.05)。结论:受免疫失衡因素影响,子宫内膜异位症患者内分泌功能多会呈现出异常状,以至于不孕症风险增加,需引起重视。
Objective: To understand the autoimmune antibody index and serum endocrine hormone status in patients with endometriosis and infertility. Methods: Thirty-three patients with endometriosis and infertility (group Ⅰ) and 33 infertility patients (n = 33) were enrolled in the Second Affiliated Hospital of Shantou University Medical College from November 2014 to February 2017 Ⅱ group), 33 cases of endometriosis (group Ⅲ) and 33 cases of physical examination (group Ⅳ). The immune antibody index and serum endocrine hormone status were analyzed. Results: The estradiol (E2) value of group Ⅱ was (140.00 ± 77.25) ng · mL -1, which was significantly higher than that of group Ⅰ, Ⅲ and Ⅳ (P <0.05) PRL, INS and testosterone were also higher than those in group Ⅰ, group Ⅲ and group Ⅳ, the difference was statistically significant (P <0.05). Conclusion: Due to the imbalance of immune factors, endocrine dysfunction in patients with endometriosis will often show abnormal shape, so that the risk of infertility increased, need attention.