定向筛选天然的β—内酰胺酶抑制剂某些病原性微生物产生β-内酰胺酶的能力与这些细菌对青霉素和头孢菌素具有耐药性之间的关系成为寻找β-内酰胺酶抑制剂的推动因素。能够有效地抑制β-内酰胺酶的物质的存在,在很大程度上可以大大扩大现有β-内酰胺抗生素治疗耐药菌引起的感染的可能性。某些半合成青霉素和头孢菌素可抑制β-内酰胺酶。很明显,这些抗生素的抑制作用与其侧链结构有关,由于仅仅在非 Directed Screening for Natural β-Lactamase Inhibitors The relationship between the ability of certain pathogenic microorganisms to produce β-lactamases and the resistance of these bacteria to penicillins and cephalosporins has led to the search for β-lactamase inhibitors The driving factor. The substance that effectively inhibits β-lactamase can greatly expand the potential of existing β-lactam antibiotics to treat infections caused by resistant bacteria. Some semi-synthetic penicillins and cephalosporins inhibit β-lactamase. Obviously, the inhibitory effect of these antibiotics and its side-chain structure, due to only non-