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目的探讨胰腺癌术后肝转移的影响因素。方法回顾性分析85例胰腺癌手术患者的临床资料,分析胰腺癌手术后肝转移的影响因素。结果单因素分析结果 :年龄、体质量指数(BMI)、是否合并脂肪肝、发病至确诊时间、是否有脉管癌栓、浸润深度、组织学分级及术后是否化疗是胰腺癌术后肝转移的影响因素(P<0.05);多因素Logistic回归分析结果显示:BMI[OR=2.824,95%CI=(1.293,3.784),P=0.002<0.05]、是否合并脂肪肝[OR=2.709,95%CI=(1.126,3.263),P=0.003<0.05]、发病至确诊时间[OR=1.673,95%CI=(1.097,2.354),P=0.005<0.05]、是否有脉管癌栓[OR=3.263,95%CI=(1.514,5.652),P=0.001<0.05]及组织学分级[OR=4.239,95%CI=(2.943,6.907),P=0.000<0.05]是胰腺癌手术后肝转移的独立影响因素。结论肥胖、发病至确诊时间长、有脉管癌栓及中低分化癌是胰腺癌术后肝转移的危险因素,而术前合并脂肪肝的胰腺癌患者术后肝转移的保护性因素。
Objective To investigate the influencing factors of postoperative liver metastasis of pancreatic cancer. Methods The clinical data of 85 patients with pancreatic cancer surgery were retrospectively analyzed. The influencing factors of liver metastasis after pancreatic cancer surgery were analyzed. Results The results of univariate analysis included age, body mass index (BMI), fatty liver disease, time from onset to diagnosis, presence of vascular tumor thrombus, depth of invasion, histological grade and whether postoperative chemotherapy was postoperative liver metastasis (OR = 2.824, 95% CI = (1.293, 3.784), P = 0.002 <0.05], with or without fatty liver [OR = 2.709, 95 (OR = 1.673, 95% CI = (1.097, 2.344), P = 0.005 <0.05], and whether there was a vascular tumor thrombus or not (OR = 1.673, 95% CI = = 3.263, 95% CI = (1.514,5.652), P = 0.001 <0.05] and histological grade [OR = 4.239,95% CI = (2.943,6.907), P = 0.000 <0.05] Independent factors of transfer. Conclusions Obese, long time to diagnosis, vascular thrombosis and moderately differentiated carcinoma are the risk factors for postoperative liver metastases in patients with pancreatic cancer, and the protective factors of hepatic metastasis in patients with pancreatic cancer with preoperative fatty liver.