本文对16例儿童期起病的微小病变型肾病综合征患者(排除系统性疾病所致)进行较长期的随访观察,以说明该型病人的后期复发情况。患者的起病年龄在7个月～10岁(平均4.3±3.1岁)。16例中男性10例,女性6例。其中10例于病程的早期行肾活检证实为微小病变型。患者对肾上腺皮质激素的治疗均敏感,多于开始治疗的8周内完全缓解(尿蛋白转阴或微量),并能维持肾功能正常,但约2/3的病人在停药后复发。其中8例因对激素依赖、频频复发或出现激素毒性作用而加用环磷酰胺(4例)或氮芥(4例)治疗,长期随访观察仍可见停用药物 This article 16 patients with childhood onset of minimal change nephrotic syndrome patients (excluding systemic diseases caused by) a more long-term follow-up observation to illustrate the type of patients with late recurrence. The onset age of patients ranged from 7 months to 10 years (mean 4.3 ± 3.1 years). Among 16 cases, 10 were male and 6 were female. Among them, 10 cases were diagnosed as minimal lesion by early renal biopsy. Patients were all more sensitive to Corticosteroid treatment than complete remission within 8 weeks of initiation of treatment (urinary protein negative or trace) and normal renal function, but about two-thirds of patients relapsed after withdrawal. Among them, 8 cases were treated with cyclophosphamide (4 cases) or nitrogen mustard (4 cases) due to hormone dependence, frequent recurrence or hormone toxicity. Long-term follow-up still showed discontinuation of drugs