一项涉及44项临床试验的荟萃研究提示,尽管多数抗心律失常药物对心房颤动(Af)转复后窦性心律的长期维持有一定疗效,但都有不良反应。基于此发现,研究者提示“IA类药物由于可增加死亡率,应当慎重使用”。Ⅲ类药物胺碘酮,预防Af复发最有效,比其他抗心律失常药物的不良反应少,与安 A meta-study involving 44 clinical trials suggests that although most anti-arrhythmic drugs have been shown to be effective in the long-term maintenance of sinus rhythm after atrial fibrillation (Af) relapse, they all have adverse effects. Based on this finding, the researchers suggest that “Class IA drugs should be used with caution due to increased mortality.” Class III drugs amiodarone, the most effective in preventing Af relapse, less adverse reactions than other anti-arrhythmic drugs, and safety