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在不同的生理条件下,垂体促性腺激素释放激素(GnRH)受体数量变化很大。当促性腺激素(GTH)对GnRH反应最大时,GnRH受体数量最高。去势后垂体GnRH受体结合GnRH能力(GnRH-BC)增加,给予性甾体或GnRH抗血清能阻止去势后GnRH受体数量与GTH浓度的增加。因此假设去势后GnRH-BC的升高是GnRH分泌增加的结果。 产生GnRH的神经分泌细胞位于下丘脑中基部(MBH),这一区域受损后,由于分泌到门脉中的GnRH消失,因此可阻止去势后GTH的升高。本工作目的:(1)明确MBH大面积损伤对于GnRH受体动态的影响;(2)阐明GnRH本
Under different physiological conditions, the number of pituitary gonadotropin-releasing hormone (GnRH) receptors varies greatly. GnRH receptors were the highest when gonadotropin (GTH) reacted to GnRH maximally. GnRH receptor binding to GnRH (GnRH-BC) increases after ghrelin administration, while administration of sex steroid or GnRH antiserum can prevent the increase of GnRH receptor quantity and GTH concentration after castration. Therefore, it is hypothesized that elevation of GnRH-BC after castration is a result of increased GnRH secretion. GnRH-producing neurosecretory cells are located in the base of the hypothalamus (MBH), which, when impaired in this area, prevents the elevation of GTH after castration due to the disappearance of GnRH secreted into the portal vein. The purpose of this work: (1) clear MBH extensive damage on GnRH receptor dynamics; (2) to clarify the GnRH