目的观察尼美舒利治疗儿童高热的退热效果和不良反应。方法选择3个月～12岁急性上呼吸道感染的发热儿童111例,随机分为2组,治疗组:口服尼美舒利;对照组:口服对乙酰氨基酚。观察体温变化及不良反应。结果尼美舒利降温作用优于对乙酰氨基酚,且药效维持时间长。结论尼美舒利治疗儿童因上呼吸道感染引起的发热具有效果快、作用强、不良反应小、使用安全等优点。 Objective To observe the antipyretic effect and adverse reactions of nimesulide in children with hyperthermia. Methods A total of 111 children with acute upper respiratory tract infection of 3 months to 12 years old were randomly divided into two groups. The treatment group was given oral nimesulide; the control group was given oral acetaminophen. Observation of body temperature changes and adverse reactions. Results Nimesulide was superior to acetaminophen in lowering the temperature, and its efficacy was prolonged. Conclusion Nimesulide treatment of children with upper respiratory tract infection caused by fever has the effect of fast, strong, adverse reactions, the use of safety and so on.