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目的探讨无精子症患者的外周血染色体核型分析和血清生殖激素水平意义。方法对324例男性无精子症患者进行了外周血染色体核型分析和血清生殖激素水平检测。结果 324例无精子症病人中检出染色体畸变62例,占19.14%。其中,性染色体异常59例,占95.16%,常染色体异常3例,占4.84%。性染色体数目异常中,核型为47,XXY者22例,46,XY/47,XXY嵌台型2例。48,XXYY者1例,46,XY大Y核型3例,46,XY小Y核型27例。无精子症组的FSH和LH水平明显高于健康对照组,差异显著(P<0.01),无精子症组的T/LH比值明显低于健康对照组,差异显著(P<0.01)。T、PRL及E_2均无明显差异。结论无精子症与染色体核型异常和生殖激素水平有密切关系。
Objective To investigate the karyotype analysis of peripheral blood and the significance of serum reproductive hormones in patients with azoospermia. Methods Peripheral blood karyotype analysis and serum reproductive hormone levels were performed in 324 male patients with azoospermia. Results Chromosomal aberrations were detected in 324 azoospermia patients, accounting for 19.14%. Among them, 59 cases of sex chromosome abnormalities, accounting for 95.16%, autosomal abnormalities in 3 cases, accounting for 4.84%. Sex chromosome abnormalities, karyotype 47, XXY in 22 cases, 46, XY / 47, XXY inset type in 2 cases. 48, XXYY in 1 case, 46, XY large Y nuclear in 3 cases, 46, XY small Y nuclear in 27 cases. The levels of FSH and LH in azoospermia group were significantly higher than those in healthy controls (P <0.01). The T / LH ratio in azoospermia group was significantly lower than that in healthy controls (P <0.01). T, PRL and E_2 no significant difference. Conclusion Azoospermia and chromosomal abnormalities and reproductive hormone levels are closely related.