新生隐球菌的感染日见增多,但继发于肝病者甚少。近年来,本院曾遇2例慢性活动性肝炎、肝硬化腹水患者,因长期使用皮质激素及多种抗菌素,而发生新生隐球菌感染死亡者。现报告如下,以引起注意。 [例1]沈××,男,40岁,住院号7578。因浮肿、腹水伴肝功能异常半年于1975年12月8日入院。患者于1971年患无黄疸型肝炎,以后迁延复发多次。入院时体检:神清,一般情况可,巩膜轻度黄染,体温正常。腹壁静脉曲张,腹部有少许移动性浊音,肝上界第五肋间,肋下未触及,剑突下2厘米,质硬,有触痛,脾肋下6厘米。下肢有凹陷性水肿。化验:胆红质(SB)1.52毫克％,谷 Cryptococcus neoformans infection increased day by day, but rarely secondary to liver disease. In recent years, our hospital has encountered two cases of chronic active hepatitis, cirrhosis and ascites patients, due to long-term use of corticosteroids and a variety of antibiotics, and the death of Cryptococcus neoformans infection occurred. Now report as follows to draw attention. [Example 1] Shen × ×, male, 40 years old, hospital number 7578. Due to edema, ascites with liver dysfunction for six months in December 8, 1975 admission. Patients in 1971 suffering from jaundice hepatitis, prolonged recurrence after repeated. Physical examination on admission: God clear, the general situation can be, scleral mild yellow dye, body temperature is normal. Abdominal varicose veins, abdominal a little shifting dullness, the fifth intercostal space of the liver, the ribs did not touch, 2 cm under the xiphoid, hard, tenderness, spleen ribs 6 cm. Depression and lower extremity edema. Assay: Bilirubin (SB) 1.52 mg%, Valley