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目的:考察复方白及乳膏中尿素的体外释放度,为合理用药提供依据。方法:采用透析袋法研究复方白及乳膏中尿素的体外释药特性,以生理盐水为释放介质,对二甲基苯甲醛试液为染色剂,分光光度法测定含量。结果:2 h内尿素累积释放度为86.0%,为速释期;48 h内累积释放度为99.0%。结论:复方白及乳膏中的尿素具有速释特性,药物释放后易被皮肤迅速吸收,2～3 h可用药一次。透析袋法考察复方白及乳膏中尿素的体外释放度,操作便利、方法稳定、结果重复性好。
OBJECTIVE: To investigate the in vitro release of urea from Fufang Baihe Cream and provide basis for rational drug use. Methods: The dialysis bag method was used to study the in vitro release of urea from Fufang Bai and cream. The physiological saline was used as the release medium and the p-dimethylbenzaldehyde test solution was used as the stain. The content of urea was determined by spectrophotometry. Results: The cumulative release of urea within 2 h was 86.0%, which was the immediate release phase. The cumulative release within 48 h was 99.0%. Conclusion: The compound white and cream urea has the characteristics of immediate release, the drug is easily absorbed quickly after the skin release, 2 ~ 3 h medication once. The dialysis bag method was used to investigate the in vitro release of urea from Compound White and Cream, with convenient operation, stable method and good reproducibility.