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目的探讨硫酸沙丁胺醇气雾剂吸入联合茶碱控释片治疗急性老年哮喘的临床疗效。方法选取2011年3月至2013年3月沈阳市红十字会医院收治的急性老年哮喘患者120例为研究对象,按随机数字表法分为研究组和对照组,每组60例。对照组患者采用硫酸沙丁胺醇气雾剂吸入治疗,研究组患者采用硫酸沙丁胺醇气雾剂吸入联合口服茶碱控释片治疗,分析两种方法对急性老年哮喘患者的治疗效果。结果两组患者治疗8周后,肺功能和哮喘病症明显好转,研究组患者的总有效率为96.7%,对照组患者的总有效率为76.7%,两组比较差异有统计学意义(P<0.05);治疗后两组患者的第1秒钟用力呼气容积均明显改善,研究组患者的好转程度明显高于对照组,差异有统计学意义(P<0.05);研究组患者的不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论采取硫酸沙丁胺醇气雾剂吸入联合茶碱控释片治疗急性老年哮喘患者效果较好,可以加快患者好转的速度,快速消除患者的支气管痉挛现象,有效缓解哮喘症状,提升肺部的呼吸功能,不良反应发生率低,效果明显高于单纯使用硫酸沙丁胺醇气雾剂吸入治疗。
Objective To investigate the clinical efficacy of salbutamol sulfate aerosol inhalation combined with theophylline controlled release tablets in the treatment of acute senile asthma. Methods A total of 120 patients with acute senile asthma admitted to Shenyang Red Cross Hospital from March 2011 to March 2013 were selected as research objects and divided into study group and control group according to random number table method, with 60 cases in each group. Patients in the control group were treated with salbutamol sulfate aerosol inhalation. Patients in the study group were treated with salbutamol sulfate aerosol inhalation combined with oral theophylline controlled release tablets. The therapeutic effect of the two methods on patients with acute senile asthma was analyzed. Results After 8 weeks of treatment, the pulmonary function and asthma symptoms improved significantly in both groups. The total effective rate was 96.7% in the study group and 76.7% in the control group, with significant difference between the two groups (P < 0.05). After the treatment, forced expiratory volume of the first second was significantly improved in both groups, and the improvement of the study group was significantly higher than that of the control group (P <0.05). The adverse reactions of the study group The incidence was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Salbutamol sulfate aerosol inhalation combined with theophylline controlled release tablets in patients with acute senile asthma is better, which can speed up the improvement of patients with rapid elimination of bronchospasm in patients with symptoms of asthma to effectively improve lung function, The incidence of adverse reactions is low, the effect was significantly higher than the simple use of salbutamol sulfate aerosol inhalation therapy.