目的探讨显微手术治疗枕大孔区脑膜瘤临床效果。方法本次观察组共选择14例枕大孔区脑膜瘤患者作研究对象,均为本院2010年6月~2013年6月收治,均采用显微手术治疗。就临床结果与前期收治的行传统开颅手术治疗的对照组10例患者进行比较。结果观察组行>90%脑膜瘤次全切除术2例,全切除术12例。术后病理检查混合型脑膜瘤4例,合体细胞型脑膜瘤4例,上皮型脑膜瘤2例,砂粒体脑膜瘤2例,未发化2例,术后2周均可离床活动,3个月机体呈正常恢复;平均行12个月随访,未见肿瘤复发或残留。与对照组比较,失语和偏瘫率居较低水平(P<0.05)。结论依据枕大孔区脑膜瘤特点,选择合适的手术入路方式,行显微手术治疗,可显著改善预后,具有非常积极的应用价值。 Objective To investigate the clinical effect of microsurgical treatment of meningioma in the foramen magnum. Methods A total of 14 patients with meningioma in the foramen magnum were selected as study subjects. All patients were admitted to our hospital from June 2010 to June 2013, all underwent microsurgical treatment. The clinical results were compared with the 10 patients in the control group who underwent traditional craniotomy for the previous period. Results In the observation group, 2 cases were treated by subtotal resection of meningioma> 90% and 12 cases by total resection. Postoperative pathological examination 4 cases of mixed meningioma, syncytial meningioma in 4 cases, epithelial meningioma in 2 cases, 2 cases of meningioma, 2 cases of non-development, 2 weeks after surgery can be separated from the bed, 3 Month body was normal recovery; average 12-month follow-up, no tumor recurrence or residual. Compared with the control group, the rates of aphasia and hemiparesis were lower (P <0.05). Conclusions According to the characteristics of meningioma in the foramen magnum, it is very positive to choose the appropriate surgical approach and microsurgical treatment to significantly improve the prognosis.