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目的通过对中国部分充分补碘地区人群血清甲状腺球蛋白的测定,以确定充分补碘地区正常人群的甲状腺球蛋白正常值范围。方法采用典型调查方法,收集中国6个地区4类目标人群(8～10岁儿童、18～45岁成人、孕妇和哺乳妇女)的晨起空腹血样,测定甲状腺球蛋白及其他甲状腺功能数据,对甲状腺功能正常人群的甲状腺球蛋白测定值进行统计分析。结果 6个地区人群甲状腺球蛋白95%正常值范围分别为:①8～10岁儿童:男(1.40,10.18)μg/L,女(1.41,11.44)μg/L;②18～45岁成人:男(1.55,39.88)μg/L,女(1.44,23.22)μg/L;③孕妇:(0.94,11.91)μg/L;④哺乳妇女:(0.12,15.05)μg/L。结论本研究建立了碘摄入正常情况下不同人群血清Tg含量的正常参考值范围,并建议将Tg纳入碘缺乏病的监测指标。
Objective To determine the normal range of thyroglobulin in the normal population in areas full of iodine by measuring serum thyroglobulin in partial iodine-rich areas of China. Methods A typical survey method was used to collect fasting blood samples from four groups of target population (8 to 10 years old, 18 to 45 years old, pregnant women and lactating women) in 6 regions of China to measure thyroglobulin and other thyroid function data. Thyroglobulin measurements were normalized in patients with normal thyroid function. Results The 95% normal range of thyroglobulin in 6 regions were as follows: ① Children aged 8-10 years: 1.40,10.18 μg / L, female 1.41,11.44 μg / L; ② Adults aged 18-45 years: 1.55,39.88) μg / L, female (1.44,23.22) μg / L; ③ pregnant women: (0.94,11.91) μg / L; ④ lactating women: (0.12,15.05) μg / L. Conclusions This study establishes a normal reference range for serum Tg in different populations under normal iodine intake and suggests that Tg be included in the monitoring of iodine deficiency disorders.