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用单纯白噪声和脉冲噪声暴露以及白噪声复合脉冲声，稳态噪声、振动、脉冲声复合作用，观察对豚鼠听器的损伤。噪声暴露前、后分别测试各组动物的听性脑干反应阈值。用ＡＢＣ免疫组织化学方法观察各组动物耳蜗肌动蛋白免疫活性。结果白噪声加脉冲声组和振动复合稳态噪声加脉冲声组动物受震前、后阈值比较有差异（Ｐ＜０．０１），而其余各组动物受震后无阈移。上述两组动物耳蜗肌动蛋白免疫活性比对照组和其它组明显减弱。提示复合因素会引起耳损伤，耳蜗内肌动蛋白活性与听阈有一定相关性。因此，在临床上应积极维护耳蜗肌动蛋白活性，以减轻损伤。
The exposure to white noise and impulsive noise and the combination of white noise composite impulse sound, steady state noise, vibration and impulsive sound were used to observe the damage of guinea pig hearing aids. Before and after noise exposure, the threshold of auditory brainstem response of each group of animals was tested. ABC immunohistochemistry was used to observe the cochlear actin immunoreactivity in each group. Results The thresholds of white noise plus pulse sound and vibrating complex steady noise plus pulse sound were significantly different before and after shock (P <0.01), while the rest animals did not show threshold shift after shock. Cochlear actin immunosuppression in both groups was significantly lower than that in the control and other groups. Suggest compound factors can cause ear injury, cochlear actin activity and hearing threshold have some relevance. Therefore, in clinical practice, cochlear actin activity should be actively maintained to reduce the damage.