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RNA interference (RNAi) is a remarkable type of generegulation based on sequence-specific targeting anddegradation of RNA.The term encompasses related pathwaysfound in a broad range of eukaryotic organisms,includingfungi,plants,and animals.RNA interference is part of asophisticated network of interconnected pathways for cellulardefense,RNA surveillance,and development and it maybecome a powerful tool to manipulate gene expressionexperimentally.RNAi technology is currently being evaluatednot only as an extremely powerful instrument for functionalgenomic analyses,but also as a potentially useful methodto develop specific dsRNA based gene-silencing therapeutics.Several laboratories have been interested in using RNAi tocontrol viral infection and many reports in Nature and inCellshow that short interfering (si) RNAs can inhibit infectionby HIV-1,polio and hepatitis C viruses in a sequence-specificmanner.RNA-based strategies for gene inhibition inmammalian cells have recently been described,which offerthe promise of antiviral therapy.
RNA interference (RNAi) is a remarkable type of generegulation based on sequence-specific targeting and degradation of RNA. The term encompasses related pathways found in a broad range of eukaryotic organisms, including fungi, plants, and animals.RNA interference is part of as established networks of interconnected pathways for cellulardefense, RNA surveillance, and development and it maybecome a powerful tool to manipulate gene expressionexperimentally. RNAi technology is currently being evaluated as an as powerful instrument for functional genomic analyzes, but also as a potentially useful methodto develop specific dsRNA based gene-silencing therapeutics.Several laboratories have been interested in using RNAi tocontrol viral infection and many reports in Nature and in Cellshow that short interfering (si) RNAs can inhibit infection by HIV-1, polio and hepatitis C viruses in a sequence-specificmanner. RNA-based strategies for gene inhibition inmammalian cells have recently been described , which offerthe promise of antiviral therapy.