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三十年前,在朝鲜战争中,有3000多名美军患了流行性出血热(EHF)。美国1954年以专论出版了关于此病的临床表现、病理生理和处理等研究结果。EHF及与其相关的流行性肾病,一直是朝鲜,斯堪的纳维亚及亚洲其他部分的一种地方病和流行病。中国有18个省有此病,最近根据临床诊断,14个省和上海市的发病率中,福建省少至每年0.03例/100,000人,而河北省多达每年12.98/100,000人。本文讨论EHF的最近进展。病原学和流行病学李氏等用间接免疫荧光法证明,临床诊断EHF病人的血清能与获自普通亚洲田鼠(黑线姬鼠)肺组织的抗原发生反应,从斯堪的纳维亚一种不同的啮齿动物(棕背(鼠平))分离的相关抗原可能是流行性肾病的致病因子。最近苏联的Tkachenko等能用酶联免疫和固相放射免疫法检测棕背(鼠平)、黑线姬鼠和丛林
Thirty years ago, more than 3,000 U.S. troops were suffering from epidemic hemorrhagic fever (EHF) during the Korean war. The United States in 1954 to monograph published about the clinical manifestations of the disease, pathophysiology and treatment and other research results. EHF and associated nephropathy have been a endemic and epidemic in North Korea, Scandinavia and other parts of Asia. In China, 18 provinces have the disease recently. According to the recent clinical diagnosis, the incidence in Fujian Province is as low as 0.03 cases / 100,000 cases per year, while in Hebei Province it is as high as 12.98 / 100,000 cases per year. This article discusses recent advances in EHF. Epidemiology and epidemiology of Lee et al. Indirect immunofluorescence demonstrated that clinically diagnosed EHF patients’ sera reacted with antigens obtained from the lung tissue of Common Asian vole (Apodemus agrarius), from Scandinavia Related antigens isolated from different rodents (brown backs) may be causative agents of epidemic nephropathy. Recently, Tkachenko et al. In the Soviet Union were able to detect brown back (rat placenta), Apodemus agrarius and jungle by enzyme-linked immunosorbent assay and solid-phase radioimmunoassay