目的　评价莫沙必利联用氟西汀治疗功能性消化不良 (FD)的疗效。方法　将 10 2例FD患者随机分为 2组。观察组 5 4例 ,给予莫沙必利 5mg ,3次 /d ,氟西汀 2 0mg ,1次 /d ;对照组 4 8例 ,给予莫沙必利 5mg ,3次 /d。疗程均为 4周 ,比较两组临床症状的变化。 结果　观察组与对照组用药 4周后临床主要症状均明显缓解 (P <0 .0 1或 0 .0 5 ) ;除恶心、呕吐和上腹部疼痛外 ,其他症状消失率观察组均优于对照组。观察组治疗总有效率为 90 .7% ,对照组为 75 .0 % ,两组相比 ,差异有显著性意义 (P <0 .0 5 )。两组患者均无严重不良反应。结论　莫沙必利联用氟西汀治疗FD疗效满意 ,安全性好 ,是目前治疗FD的可行方案。 Objective To evaluate the efficacy of mosapride combined with fluoxetine in the treatment of functional dyspepsia (FD). Methods 102 patients with FD were randomly divided into two groups. Observation group of 54 cases, given mosapride 5mg, 3 times / d, fluoxetine 20mg, 1 / d; control group, 48 cases, given mosapride 5mg, 3 times / d. The course of treatment was 4 weeks, and the changes of clinical symptoms were compared between the two groups. Results The clinical symptoms of the observation group and the control group were significantly relieved after 4 weeks of treatment (P <0.01 or 0.55). Except for nausea, vomiting and upper abdominal pain, the observation group of other symptoms disappeared in the observation group were better than the control group group. The observation group, the total effective rate was 90.7%, 75.0% in the control group, compared with the two groups, the difference was significant (P <0. Two groups of patients without serious adverse reactions. Conclusion Mosapride combined with fluoxetine in the treatment of FD is effective and safe, and it is a feasible solution for the treatment of FD.