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慢性肝病中,肝细胞作为单能干细胞参与肝脏修复,还存在类似于动物致癌、损伤模型中卵圆细胞的肝干细胞或肝前体细胞,这些细胞均能活化并分化成肝细胞和胆管上皮,与临床慢性肝病的发生发展密切相关,主要包括胆管反应中的卵圆细胞和小肝细胞,定位于Hering管、汇管区、纤维间隔、汇管区旁肝实质、假小叶及炎症边界,根据超微结构特点分为三型,可以表达一系列标记物,还可能是骨髓、胰腺来源。
In chronic liver disease, hepatocytes participate in liver repair as single-function stem cells, and there are hepatic stem cells or hepatic precursor cells similar to oval cells in animal carcinogenesis and injury models. All of these cells can activate and differentiate into hepatocytes and biliary epithelium, It is closely related to the occurrence and development of clinical chronic liver disease. It mainly includes oval cells and small hepatocytes in the bile duct reaction. It is located in the Hering duct, portal area, fibroids, paravertebral hepatic parenchyma, pseudolobule and inflammatory border. Structural characteristics are divided into three types, can express a series of markers, but also may be bone marrow, pancreatic origin.