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目的探讨纤维蛋白原(FIB)、超敏C反应蛋白(hs-CRP)、尿酸(UA)对冠心病的诊断、治疗及预后的临床指导意义。方法选择87例冠脉造影已经确诊的冠心病(CHD)患者且无严重感染、外伤、肿瘤等疾病为CHD组,根据临床分类分为稳定型心绞痛(SAP)、不稳定型心绞痛(UAP)、急性心肌梗死(AMI)三组。133例健康体检者为对照组,分别检测血清标本中FIB、hs-CRP、UA浓度。结果 CHD组血清FIB、hs-CRP、UA均高于对照组(P<0.05);FIB、hs-CRP、UA在SAP组、UAP组、AMI组依次均增高,差异有统计学意义(P<0.05)。结论 FIB、hs-CRP、UA血清浓度测定有助于指导临床医生CHD诊断、治疗、病情评估。
Objective To investigate the clinical significance of fibrinogen (FIB), hs-CRP and uric acid (UA) in the diagnosis, treatment and prognosis of coronary heart disease. Methods Eighty-seven patients with coronary heart disease (CHD) who had been confirmed by coronary angiography were enrolled in the study. There were no serious infections, traumatic diseases and neoplasms were diagnosed as CHD. According to clinical classification, they were divided into stable angina pectoris (SAP), unstable angina pectoris (UAP) Acute myocardial infarction (AMI) three groups. 133 healthy volunteers as control group were detected serum samples FIB, hs-CRP, UA concentration. Results The serum levels of FIB, hs-CRP and UA in CHD group were significantly higher than those in control group (P <0.05). The levels of FIB, hs-CRP and UA in SAP group, UAP group and AMI group were significantly increased 0.05). Conclusion The serum concentrations of FIB, hs-CRP and UA are helpful to guide clinicians in the diagnosis, treatment and assessment of CHD.