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目的 观察国产尼索地平治疗Ⅱ级原发性高血压的临床疗效。方法 选择100 例Ⅱ级原发性高血压患者(男性65例,女性35例),随机分为尼索地平治疗组(n=51,尼索地平片10mg, 每天2次,口服)和尼索地平+消心痛治疗组(n=49,尼索地平10mg, 每天2次,口服;消心痛片10mg,每天3 次,口服)。结果 尼索地平治疗组:显效32%,有效61%,无效7%。尼索地平+消心痛治疗组: 显效64%,有效32%,无效4%。两组相比,显效率有显著性差异(P<0.05)。结论 服用国产尼索地平治疗Ⅱ级原发性高血压安全、有效,副作用少,大多能耐受,与消心痛合用其降压效果加强。
Objective To observe the clinical efficacy of domestic nisoldipine in the treatment of grade Ⅱ essential hypertension. Methods 100 patients with grade Ⅱ essential hypertension (65 males and 35 females) were randomly divided into 3 groups: nisoldipine treatment group (n = 51, nisoldipine tablets 10 mg twice a day, oral) Treatment group (n = 49, nisoldipine 10mg, twice daily, oral; wacker heart tablets 10mg, 3 times a day, orally). Results Nisoldipine treatment group: markedly effective 32%, effective 61%, invalid 7%. Nisoldipine + Xiao Hua Tong treatment group: markedly effective 64%, effective 32%, invalid 4%. Significant difference was found between two groups (P <0.05). Conclusion The treatment of nifedipine in patients with grade Ⅱ essential hypertension is safe, effective and has few side effects. Most patients are able to tolerate it and their antihypertensive effect is enhanced with the combination of Xiao Xin and heartburn.