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目的:探讨局部注射药物联合口服康复新液辅助治疗颈淋巴结结核的临床疗效及安全性。方法:按照随机数字表法将2010年1月-2014年1月我院收治的140例颈淋巴结结核患者分为对照组(n=70)和观察组(n=70),对照组口服异烟肼、利福平、乙胺丁醇、吡嗪酰胺及肌注链霉素进行全身抗结核治疗,观察组在对照组的基础上局部注射异烟肼、链霉素粉联合口服康复新液治疗。比较两组患者治疗后1个月、3个月及6个月症状缓解率,淋巴结吸收率,治疗后3个月复发率及不良反应发生率。结果:观察组治疗后1个月、3个月及6个月的症状缓解率、淋巴结吸收率均高于对照组(P<0.05)。治疗后3个月,观察组复发率为2.86%,显著低于对照组的11.43%(P<0.05)。观察组恶心、局部反应、白细胞减少及肝功能损害发生率均低于对照组(P<0.05)。结论:局部注射抗结核药物联合口服康复新液辅助治疗颈淋巴结结核可提高患者的症状缓解率和淋巴结吸收率,且安全性高,有重要的临床推广价值。
Objective: To investigate the clinical efficacy and safety of topical injection and oral rehabilitation of new liquid adjuvant treatment of cervical lymph node tuberculosis. Methods: According to the random number table method, 140 patients with cervical lymph node tuberculosis admitted to our hospital from January 2010 to January 2014 were divided into control group (n = 70) and observation group (n = 70) Hydrazide, rifampin, ethambutol, pyrazinamide and streptomycin were administered to patients with systemic antituberculous therapy. The observation group was treated with isoniazid and streptomycin powder in combination with oral rehabilitation liquid on the basis of the control group . Two groups of patients after treatment 1 month, 3 months and 6 months symptom relief rate, lymph node absorption rate, 3 months after treatment, the recurrence rate and the incidence of adverse reactions. Results: The symptom relief rate and lymph node absorption rate in observation group at one month, three months and six months after treatment were higher than those in control group (P <0.05). At 3 months after treatment, the recurrence rate in observation group was 2.86%, which was significantly lower than that in control group (11.43%, P <0.05). The incidence of nausea, local reactions, leukopenia and hepatic dysfunction in observation group were lower than those in control group (P <0.05). Conclusion: The combination of topical injection of anti-tuberculosis drugs and oral rehabilitation of new liquid adjuvant treatment of cervical lymph node tuberculosis can improve the patient’s symptoms and lymph node absorption rate, and high safety, and has important clinical value.