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用等电聚焦电泳（IEF）和Western－blot技术检测125例Ⅱ型糖尿病患者血清apoA－Ⅳ的基因频率、表型分布和血清水平，以了解Ⅱ型糖尿病患者apoA－Ⅳ的多态性及其与apoA－Ⅳ血清水平的关系。结果显示：Ⅱ型糖尿病患者apoA-Ⅳ的两个常见等位基因频率为：apoA-Ⅳ*1=0.9960，apoA-Ⅳ*2=0；两个常见表型的分布为：apoA－Ⅳ1-1=99．2％，apoA－Ⅳ2-1=0；apoA－Ⅳ的血清水平为0.0262±0．0125g／L，与健康人群组相比较，apoA－Ⅳ多态性没有显著性差异（P＞0．75，P＞0．25），其血清水平显著增高（P＜0．001）。结论；Ⅱ型糖尿病患者apoA－Ⅳ的多态性不是发病的决定因素。
The plasma levels of apoA-Ⅳ gene in 125 patients with type 2 diabetes mellitus were detected by isoelectric focusing (IEF) and Western-blot technique to understand the polymorphism of apoA-IV in type 2 diabetes mellitus And apoA-IV serum levels. The results showed that the two common alleles of apoA-IV in patients with type 2 diabetes were apoA-IV * 1 = 0.9960 and apoA-IV * 2 = 0. The distribution of two common phenotypes was apoA-IV1-1 = 99.2%, apoA-Ⅳ2-1 = 0; serum level of apoA-Ⅳ was 0.0262 ± 0.0125g / L, there was no significant difference in apoA-Ⅳ polymorphism compared with healthy people (P> 0.75, P> 0.25), the serum level was significantly higher (P <0.001). Conclusion: The polymorphism of apoA-Ⅳ in type Ⅱ diabetic patients is not the determinant factor.