单克隆γ球蛋白病是一组与浆细胞单克隆增殖有关的疾病。2003年,国际骨髓瘤工作组将未明确意义的单克隆γ球蛋白病(Monoclonal Gammopathy of Undetermined Significance,MGUS)定义为:病人血清单克隆蛋白(M蛋白)<3g/dl和骨髓浆细胞比值<10%,并且临床上无任何多发性骨髓瘤、巨球蛋白血症、原发性淀粉样变性及其它相关的浆细胞和淋巴细胞增殖性疾病的临床 Monoclonal gamma globulin disease is a group of diseases associated with proliferation of plasma cells. In 2003, the International Myeloma Working Group defined the unambiguously defined Monoclonal Gammopathy of Undetermined Significance (MGUS) as a combination of patient serum monoclonal protein (M protein) <3 g / dl and bone marrow plasma cell ratio < 10%, and clinical clinical without any multiple myeloma, macroglobulinemia, primary amyloidosis and other related plasma cells and lymphoproliferative diseases