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作者等用X线照射的子孢子,按不同的时间及不同剂量的抗原接种A/J小白鼠,以研究保护性免疫和抗子孢子(环子孢子沉淀)抗体的产生。研究的方法主要是以环子孢子沉淀测定抗子孢子抗体的存在,并在免疫小白鼠和对照组用攻击接种测定保护性免疫的效果。通过环子孢子沉淀试验检出抗体的产生和持续的时间,并与保护性免疫的有效时间比较,便可查明抗体的产生和保护性免疫的关系。同时还获得有关X线照射和非照射的子孢子免疫作用的比较数据。在1次免疫接种(1.5×10~5或7.5×10~4个X线照射的子孢子)后,许多小白鼠对攻击接种具有完全的保护效果,但是,被保护动物的百分比,在每
The authors used X-ray sporozoites, and A / J mice were inoculated with antigens at different times and doses to study the protective immunity and the production of anti-sporozoite antibodies. The main method of the study is the determination of the presence of anti-sporozoite antibodies by circumsporozoite precipitation and the effect of protective vaccination by immunization on immunized mice and controls. Antibody production and duration were detected by circumsporozoite precipitation assay and the relationship between antibody production and protective immunity was determined by comparison with the duration of protective immunity. Also obtained on the X-ray irradiation and non-irradiated sporozoites of the comparative data. After one immunization (1.5 × 10 -5 or 7.5 × 10-4 sporozoites irradiated with X-rays), many mice had a complete protective effect on challenge vaccination, however, the percentage of protected animals at each