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目的探讨慢性丙肝(CHC)患者治疗前后血清尿酸水平的变化。方法选择武汉大学人民医院感染科83例CHC患者,跟踪其治疗过程。SIEMENS公司生产的ADVIA2400全自动生化分析仪测定其血清中尿酸浓度。结果 CHC患者接受治疗后,应答组患者尿酸水平高于无应答组,差异有统计学意义(t=1.89,P<0.05)。CHC患者治疗前和治疗后,男性患者尿酸水平高于女性患者,差异有统计学意义(治疗前t=2.75,治疗后t=2.65,P<0.05)。CHC患者治疗前,中年组尿酸水平低于青年组和老年组患者,差异有统计学意义(F=5.66,P<0.05);但CHC患者治疗后,中年组尿酸水平与青年组和老年组患者比较差异无统计学意义(F=1.76,P>0.05)。结论 CHC患者的治疗对其尿酸的水平有影响,应在治疗过程中予以监测。
Objective To investigate the changes of serum uric acid levels in patients with chronic hepatitis C before and after treatment. Methods 83 cases of CHC patients from Department of Infectious Diseases, People’s Hospital of Wuhan University were selected and the course of treatment was followed up. The ADVIA2400 automatic biochemical analyzer produced by SIEMENS measured the serum uric acid concentration. Results After CHC treatment, the level of uric acid in response group was higher than that in non-response group, the difference was statistically significant (t = 1.89, P <0.05). The levels of uric acid in male patients before and after CHC treatment were significantly higher than those in female patients (t = 2.75 before treatment, t = 2.65 after treatment, P <0.05). The levels of uric acid in CHC patients before and after middle-aged were lower than those in youth and elderly patients (F = 5.66, P <0.05). However, after CHC treatment, There was no significant difference between the two groups (F = 1.76, P> 0.05). Conclusion Treatment of CHC affects uric acid levels and should be monitored during treatment.