本文目的为定性和定量地比较动物与人对长春新硷(VGR)的毒性剂量反应。VGR 的临床前毒性研究是在狗和猴上进行的,所有动物皆为静脉注射,每周一次,共六周。在给予0.08毫克/公斤的四只狗中,有两只狗分别于试验的32天和39天死亡,其中一只死于小肠严重退行性变和坏死,导致终局性脓血症,另一只则死于坏疽性肺炎。其他病变为淋巴细胞发 The purpose of this paper is to qualitatively and quantitatively compare the toxic dose response of animals and humans to vincristine (VGR). Preclinical toxicity studies of VGR were performed on dogs and monkeys, all of which were given intravenously once a week for six weeks. Of the four dogs given 0.08 mg / kg, two dogs died on days 32 and 39 of the trial, respectively, one of which died of serious degenerative changes and necrosis of the small intestine resulting in a final sepsis and the other Died of gangrenous pneumonia. Other lesions are lymphocytes