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The present study was designed to identify potent anti-tumor compounds from a series of new longistylin C derivatives.Ten longistylin C derivatives were synthesized and their structures were confirmed by ~1H NMR,MS,and elemental analyses.Their cytotoxicity in vitro against three human cancer cell lines(A549,HepG2,and MCF-7) were evaluated by the MTT assay.Among these compounds,DT-6 and DT-9 displayed much better cytotoxicity against A549,HepG2,and MCF-7 cells,DT-1 exhibited selective cytotoxicity against HepG2,and the structure-activity relationships were investigated.In conclusion,Compounds DT-6 and DT-9 may serve as potential lead compounds for the discovery of new anti-cancer drugs.
The present study was designed to identify potent anti-tumor compounds from a series of new longistylin C derivatives. Ten longistylin C derivatives were synthesized and their structures were confirmed by ~ 1H NMR, MS, and elemental analyzes. Their cytotoxicity in vitro against three human Cell lines (A549, HepG2, and MCF-7) were evaluated by the MTT assay. Amm these compounds, DT-6 and DT-9 exhibited much better cytotoxicity against A549, HepG2, and MCF- selective cytotoxicity against HepG2, and the structure-activity relationships were investigated. In conclusion, Compounds DT-6 and DT-9 may serve as potential lead compounds for the discovery of new anti-cancer drugs.