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目的:探讨负压引流在胃切除术后十二指肠残端瘘治疗中的作用。方法:回顾性分析2016年1月至2020年1月本科收治的36例胃切除术后十二指肠残端瘘患者资料，根据发生肠瘘时患者的引流方式分为负压引流组(观察组)18例，常规橡胶管引流组(对照组)18例，观察两组患者的并发症发生率及肠瘘愈合时间。结果:观察组患者并发症发生率[5.56%(1/18)]与对照组[11.11%(2/18)]比较差异无统计学意义(n P>0.05)。观察组患者肠瘘愈合时间[(12.83±6.25)d]与对照组[(23.33±4.64)d]比较差异有统计学意义(n P0.05) in the incidence of complications between the observation group (5.56%) and the control group (11.11%). There was a significant difference in the mean healing time between the observation group [(12.83±6.25)days] and the control group [(23.33±4.64)days] (n P<0.05).n Conclusions:Negative pressure drainage is beneficial to the healing of duodenal stump fistula, and does not improve the incidence of postoperative complications. It is safe and effective. It can be used as a conventional drainage for gastrectomy.