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目的探讨脱水药保守治疗颅内高压的临床效果。方法选取2010年4月-2012年3月期间我院收治的颅内高压患者104例,随机分为3组。分别给予不同剂量的甘露醇或联合速尿进行治疗,统计三组患者有效率、反跳率、药效持续时间、颅内压降低幅度等指标。结果三组治疗方法中,A、B两组的有效率和反跳率相差不大,无统计学意义(P>0.05);而与C组相比,两组有效率明显较低,而反跳率则明显较高,有统计学意义(P<0.05);三组患者药效持续时间以C组最久,而A组最短,三组之间比较差异明显,有统计学意义(P<0.05);三组患者降低颅内压的幅度相差不大,无统计学意义(P>0.05)。结论甘露醇与速尿联合应用治疗颅内高压是一种有效而安全的方式,在临床工作中可以作为一种常规的方式进行推广。
Objective To investigate the clinical effect of conservative treatment of intracranial hypertension with dehydrated medicine. Methods 104 patients with intracranial hypertension treated in our hospital from April 2010 to March 2012 were randomly divided into three groups. Were given different doses of mannitol or furosemide treatment, statistics three groups of patients with efficiency, rebound rate, duration of efficacy, decreased intracranial pressure and other indicators. Results Among the three treatment methods, the effective rate and the rate of rebound in group A and B were similar with no significant difference (P> 0.05), but the effective rate was significantly lower in group A and group B than in group C (P <0.05). The duration of efficacy of the three groups was the longest in group C and the shortest in group A, with significant difference between the three groups (P <0.05), the difference was statistically significant (P < 0.05). There was no significant difference between the three groups in decreasing the intracranial pressure amplitude (P> 0.05). Conclusion The combination of mannitol and furosemide in the treatment of intracranial hypertension is an effective and safe way, which can be popularized in clinic as a regular way.