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目的:观察射频消融早期对兔肝VX2肿瘤细胞增殖的影响。方法:将试验兔分为2组:A组(对照组)不行射频消融治疗;B组(射频消融组、残瘤组),观察射频消融后不同时期的病理表现及肺转移情况。结果:射频消融后2,7d,B组增殖细胞核抗原指数明显低于同期A组,2组比较差异有统计学意义(P<0.05)。射频消融后14 d B组增殖细胞核抗原指数较前增加,但与A组比较差异无统计学意义(P>0.05)。射频消融后2,14 d,2组肺转移率差异无统计学意义(P>0.05)。射频消融后7 d,2组肺转移率差异有统计学意义(P<0.05)。结论:射频消融早期对残余肿瘤细胞增殖及肺转移有抑制作用。
Objective: To observe the effect of early radiofrequency ablation on the proliferation of rabbit hepatic VX2 tumor cells. Methods: The rabbits were divided into 2 groups: group A (control group) did not radiofrequency ablation; group B (radiofrequency ablation group, residual tumor group), pathological findings at different periods after radiofrequency ablation and lung metastasis. Results: At 2 and 7 days after radiofrequency ablation, the index of proliferating cell nuclear antigen in group B was significantly lower than that in group A at the same period (P <0.05). On the 14th day after radiofrequency ablation, the index of proliferating cell nuclear antigen in group B was increased compared with the previous group, but there was no significant difference compared with group A (P> 0.05). There was no significant difference in lung metastasis rate between 2 and 14 days after radiofrequency ablation (P> 0.05). Seven days after radiofrequency ablation, there was a significant difference in lung metastasis rate between the two groups (P <0.05). Conclusion: Radiofrequency ablation early on residual tumor cell proliferation and lung metastasis.