论文部分内容阅读
为了解居民饮富砷水与肺癌死亡之间的流行病学关系，采用历史性前瞻的研究方法，研究了８８５人２３年来的资料，结果表明：砷暴露组肺癌的死亡率（１３３．７０／１０万人年）显著高于非暴露组（９．９５／１０万人年），Ｐ＜０．０１，相对危险度为１３．４４。总砷摄入量与肺癌相对危险性之间呈明显的剂量反应关系对钝顶螺旋藻的抗突变作用进行了研究。结果表明：钝顶螺旋藻在２０００ｍｇ／ｋｇ剂量下，对环磷酰胺所致小鼠骨髓细胞微核增加有拮抗作用（Ｐ＜０．０５），对丝裂霉素所致小鼠睾丸染色体畸变在染色体畸变细胞率指标上具有拮抗作用（Ｐ＜０．０５），在性染色体单价体，常染色体单价体，具有拮抗趋势，但无统计学意义（Ｐ＞０．０５）。在６７，６７０ｍｇ／ｋｇ两个低剂量下，对环磷酰胺所致小鼠骨髓细胞微核和对丝裂霉素所致小鼠睾丸染色体畸变在染色体畸变细胞率增高的拮抗作用无统计学差异（Ｐ＞０．０５）。
In order to understand the epidemiological relationship between arsenic-rich drinking water and lung cancer death, a historically prospective research method was used to study the data of 885 people over 23 years. The results showed that the mortality rate of lung cancer in the arsenic-exposed group (133.70/ 100,000 person-years) was significantly higher than the non-exposed group (9.95/10 million person-years), P<0.01, relative risk was 13.44. The relationship between the total arsenic intake and the relative risk of lung cancer showed a significant dose-response relationship and the antimutagenic effect of Spirulina platensis was studied. The results showed that Spirulina platensis had an antagonistic effect on the increase of micronucleus of bone marrow cells in mice induced by cyclophosphamide at a dose of 2000 mg/kg (P<0.05). The chromosomal aberration of mouse testis induced by mitomycin was observed. There was an antagonistic effect on the rate of chromosomal aberrations (P<0.05). There was a trend of antagonism in the univalent body of sex chromosomes and univalent body of autosomes, but there was no statistical significance (P>0.05). At the two low doses of 67,670 mg/kg, there was no statistical difference in the antagonistic effect of cyclophosphamide-induced micronucleus formation in mouse bone marrow cells and mitomycin-induced chromosomal aberrations in mouse chromosome aberrations. (P>0.05).