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一、青霉素与四环素、氯霉素及红霉素的相互作用:青霉素的杀菌作用,可被后三者所拮抗。这是因为:①青霉素与细菌细胞壁粘肽合成中的转肽酶结合,可抑制氨基酸的交叉连接,影响细胞壁粘肽的合成;而四环素、氯霉素及红霉素则能促进细菌细胞壁粘肽对氨基酸的摄取,从而加速细胞壁的合成,与青霉素的作用恰好相反。②青霉素是繁殖期杀菌剂,对繁殖旺盛的细菌作用显著,而四环素、氯霉素及红霉素是速效抑菌剂,可抑制细菌蛋白质
First, the interaction of penicillin and tetracycline, chloramphenicol and erythromycin: bactericidal effect of penicillin can be antagonized by the latter three. This is because: ① penicillin and bacterial cell wall mucins synthesis of transpeptidase binding, can inhibit the cross-linking of amino acids, affecting the synthesis of cell wall mucins; and tetracycline, chloramphenicol and erythromycin can promote bacterial cell wall mucin Amino acid intake, thereby accelerating the synthesis of cell walls, and the role of penicillin on the contrary. ② penicillin is a breeding season fungicide, a significant role in the reproduction of strong bacteria, and tetracycline, chloramphenicol and erythromycin is a fast-acting bacteriostatic agent that can inhibit bacterial proteins