水性滴眼剂是用于治疗眼部疾病的传统剂型,由于药物随泪液快速流失致使其生物利用度较低。为了维持治疗水平必须频繁地滴药液,从而给病人带来极大的不便。为提高药物生物利用度,已开发了许多眼用药物释放系统,包括微球、纳米微粒、脂质体和眼部嵌入剂。眼部嵌入剂为直接放在眼 Aqueous eye drops are the traditional dosage forms for the treatment of eye diseases and their bioavailability is low due to the rapid loss of drug with tear fluid. In order to maintain the level of treatment must be frequent drops, resulting in great inconvenience to the patient. To improve drug bioavailability, a number of ophthalmic drug delivery systems have been developed, including microspheres, nanoparticles, liposomes, and eye intercalators. Eye intercalators are placed directly on the eye