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硫脲类药丙基硫氧嘧啶(PTU)和他巴唑(MMI)是治疗Graves病最广泛应用的药物,但每日用量与其副作用之间的相互关系,至今尚未肯定。大剂量可能作用于本病的免疫性异常,而一般低剂量则仅能控制甲状腺素的过量产生。作者曾证实,用大剂量治疗Graves甲亢,比用低剂量有较高缓解率,但临床医生常不敢开大剂量处方,因其不良反应与大剂量有关。本研究目的在于评估不良反应与用药剂量的关系。
Thioureas Propylthiouracil (PTU) and methimazole (MMI) are the most widely used drugs for the treatment of Graves disease, but the relationship between daily doses and their side effects has not yet been confirmed. Large doses may act on the immune abnormalities, and generally low dose can only control the excessive production of thyroxine. The authors have confirmed that with high-dose treatment of Graves hyperthyroidism than with low doses have a higher response rate, but clinicians often afraid to open large doses of prescription because of its adverse reactions and high doses. The purpose of this study was to assess the relationship between adverse reactions and dose.