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目的探讨2型糖尿病患者尿白蛋白排泄率与血脂的关系。方法无尿路感染及原发性肾脏疾病病史的2型糖尿病患者68例,按尿白蛋白排泄率分为正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组。检测所有患者的空腹血糖、糖化血红蛋白、血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇。结果微量白蛋白尿组和大量白蛋白尿组空腹血糖、糖化血红蛋白、收缩压和舒张压均高于正常白蛋白尿组;大量白蛋白尿组的空腹血糖、糖化血红蛋白、收缩压和舒张压均较微量白蛋白尿组高。微量白蛋白尿组和大量白蛋白尿组血清甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平均高于正常白蛋白尿组;大量白蛋白尿组血清甘油三酯、总胆固醇和低密度脂蛋白胆固醇较微量白蛋白尿组高。3组血清高密度脂蛋白胆固醇水平无统计学意义(P>0.05)。结论2型糖尿病患者尿白蛋白排泄率不仅与糖代谢指标和血压有关,与血脂也存在相关性,提示脂质代谢紊乱在糖尿病肾病的发生、发展中可能起一定的作用。
Objective To investigate the relationship between urinary albumin excretion and blood lipids in type 2 diabetic patients. Methods Sixty-eight type 2 diabetic patients without history of urinary tract infection and primary kidney disease were divided into normal albuminuria group, microalbuminuria group and large albuminuria group according to urinary albumin excretion rate. Fasting blood glucose, glycosylated hemoglobin, serum triglycerides, total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol were measured in all patients. Results The levels of fasting blood glucose, glycosylated hemoglobin, systolic pressure and diastolic pressure in patients with microalbuminuria and macroalbuminuria were significantly higher than those with normal albuminuria. Fasting blood glucose, glycosylated hemoglobin, systolic and diastolic blood pressure Higher than the microalbuminuria group. Serum triglycerides, total cholesterol and low density lipoprotein cholesterol in microalbuminuria group and in a large amount of albuminuria group were higher than those in normal albuminuria group. Serum triglyceride, total cholesterol and low density lipoprotein Protein cholesterol is higher than microalbuminuria group. There was no significant difference in serum high-density lipoprotein cholesterol among the three groups (P> 0.05). Conclusion The urinary albumin excretion rate in patients with type 2 diabetes mellitus is not only related to glucose metabolism index and blood pressure, but also to the lipid profile, suggesting that lipid metabolism disorder may play a role in the occurrence and development of diabetic nephropathy.