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钛合金具有优良的综合性能,作为医用金属植入材料广泛应用于临床医学,而在钛合金植入物表面进行微造型有助于提高钛合金的生物相容性。采用1064nm波长的皮秒激光在钛合金(Ti-6Al-4V)表面进行微造型实验,并验证微造型的生物相容性。设计正交实验,通过扫描电子显微镜、扫描探针显微镜和共聚焦显微镜分析了样件表面形貌,建立微造型几何尺寸与激光参数的关系,确立了最优工艺参数,完成钛合金微造型样件制备。进行了大鼠骨髓间充质干细胞培养和免疫荧光观察细胞骨架实验。实验表明,微造型对细胞生长起到促进和引导作用。
Titanium alloy has excellent comprehensive performance, which is widely used in clinical medicine as a medical metal implant material. Micro-molding on the surface of the titanium alloy implant helps to improve the biocompatibility of the titanium alloy. The picosecond laser with a wavelength of 1064 nm was used to perform micro-modeling on the surface of titanium alloy (Ti-6Al-4V) and to verify the biocompatibility of micro-modeling. The orthogonal experiment was designed. The surface morphology of the sample was analyzed by scanning electron microscope, scanning probe microscope and confocal microscope. The relationship between the micro-shape geometry and the laser parameters was established. The optimal process parameters were established and the titanium alloy micro- Preparation. Rat bone marrow mesenchymal stem cells were cultured and immunofluorescence cytoskeleton experiments. Experiments show that micro-modeling can promote and guide cell growth.