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肥胖是一种炎症性疾病,许多炎症因子与肥胖和糖尿病的发生发展密切相关。研究炎症因子及其信号转导通路机制可能为肥胖、糖尿病的预防和治疗提供全新的理论基础。姜黄素具有抗炎、抗凝、降血脂、抗氧化、清除自由基、抗动脉粥样硬化及抑制肿瘤生长等多方面的功能,其作为治疗多种疾病的潜力药物正引起越来越多的关注。本文对姜黄素的抗炎作用,以及具有潜在的防治肥胖和糖尿病作用的研究进展做一综述。
Obesity is an inflammatory disease, many inflammatory factors and obesity and diabetes are closely related to the occurrence and development. Studying the mechanism of inflammatory factors and their signal transduction pathways may provide a new theoretical basis for the prevention and treatment of obesity and diabetes. Curcumin has many functions such as anti-inflammatory, anticoagulant, hypolipidemic, anti-oxidant, free radical scavenging, anti-atherosclerosis and tumor growth inhibition. As a potential drug for treating various diseases, curcumin is causing more and more attention. This review summarizes the anti-inflammatory effects of curcumin and its potential role in prevention and treatment of obesity and diabetes.