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建立经鼠视神经孔注血致蛛网膜下腔出血（ＳＡＨ）的动物模型，并间隔４８、９６小时３次注血，以探讨其致脑血管痉挛（ＣＶＳ）的病理特点。结果发现注血后基底池多量积血。３次注血的第２天，颅底动脉内皮细胞肿胀，胞浆出现空泡，有的内皮下基质增多，平滑肌细胞变形，不规则圆形或多角状突起，血管外膜炎细胞浸润。３次注血的第５天，内膜水肿略好转。认为３次经视神经孔注血可以引起轻度脑动脉痉挛的病理改变。本文就本类型动物模型的优点作了讨论
An animal model of subarachnoid hemorrhage (SAH) caused by intracerebral optic nerve perfusion was established and injected at intervals of 48 and 96 hours to investigate the pathological features of cerebrovascular vasospasm (CVS). The results found after injection of blood pool basal pool. On the second day after 3 times of injection, the endothelial cells of the skull base artery were swollen with vacuolation in the cytoplasm, increased in the subendothelial stroma, deformation of smooth muscle cells, irregular round or polygonal protrusions, and infiltration of extravascular membrane cells. On the 5th day of 3 injection, the intima edema improved slightly. That the 3 times through the optic nerve hole injection can cause pathological changes of mild cerebral artery spasm. This article discusses the advantages of this type of animal model