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目的探讨紫杉醇与顺铂联合化疗不同给药途径治疗晚期卵巢癌的疗效观察。方法 54例晚期卵巢癌患者,按紫杉醇与顺铂的不同给药途径进行分组:静脉给药治疗的患者26例设为对照组,腹腔内给药治疗的患者28例设为观察组,分析两组治疗效果的差异是否有统计学意义。结果观察组治疗完全缓解9例,部分缓解者14例,无变化及进展者5例,总有效率82.1%;对照组治疗完全缓解4例,部分缓解者8例,无变化及进展者14例,总有效率46.1%。两组治疗效果的差异具有统计学意义(P<0.05)。结论紫杉醇与顺铂联合化疗治疗晚期卵巢癌经腹腔内给药临床疗效较好。
Objective To investigate the efficacy of paclitaxel combined with cisplatin in the treatment of advanced ovarian cancer by different routes of administration. Methods Totally 54 patients with advanced ovarian cancer were divided into different groups according to the different routes of administration of paclitaxel and cisplatin. Twenty-six patients treated by intravenous injection were set as the control group, and 28 patients treated by intraperitoneal injection were treated as observation group. Group differences in the treatment effect is statistically significant. Results The observation group received complete remission in 9 cases, partial remission in 14 cases, no change and progress in 5 cases, the total effective rate was 82.1%; control group 4 cases of complete remission, partial remission in 8 cases, no change and progress in 14 cases , The total efficiency of 46.1%. The differences between the two groups were statistically significant (P <0.05). Conclusion paclitaxel combined with cisplatin in the treatment of advanced ovarian cancer by intraperitoneal administration of good clinical efficacy.