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男性生殖器硬化性苔藓样病(MGLSc)是一种慢性复发性疾病,病程较长,逐渐加重,并有恶变倾向。该病既往被称为闭塞性干燥性阴茎头炎(BXO),主要发生于包皮、阴茎头,疾病进行性进展可累及尿道,形成瘢痕组织而引起尿道狭窄,出现尿线变细、排尿困难及痛性勃起,严重影响患者生活质量。该病的病因及发病机制目前尚不明确,普遍认为与自身免疫、遗传、感染、局部创伤及尿液慢性刺激有关。通过临床表现并结合病理检查该病不难确诊,重点在于早期诊断及治疗。该病很难被治愈,但是通过积极的治疗可以减轻症状、阻止疾病进展,有效阻断远期后遗症的发生。局部皮质类固醇类药物是MGLSc治疗的首选药物,对于药物保守治疗无效者和尿道狭窄引起的排尿梗阻及痛性勃起者,可采用合理的手术方式进行手术治疗,并重视长期随访。本文对MGLSc及其所致的尿道狭窄的诊治现状作一综述,以期对该病的诊治有所提高。
Male genital scleroses lichenoid disease (MGLSc) is a chronic recurrent disease, longer duration, and gradually increased, and malignant tendency. The disease, formerly known as occlusive dry glaucoma (BXO), occurs primarily in the foreskin and glans penis. Progressive progression of the disease can involve the urethra, cause scar formation and cause urethral stricture, thinning of the urinary tract, difficulty urinating, and Erectile dysfunction, seriously affecting the quality of life of patients. The etiology and pathogenesis of the disease is not yet clear, generally believed to be associated with autoimmune, genetic, infection, local trauma and chronic urinary stimulation. Through clinical manifestations combined with pathological examination of the disease is not difficult to diagnose, the focus is on early diagnosis and treatment. The disease is difficult to be cured, but through active treatment can reduce the symptoms, prevent disease progression, effectively blocking the occurrence of long-term sequelae. Topical corticosteroids are the drug of choice for the treatment of MGLSc, for conservative treatment of drug ineffective urethral obstruction and pain caused by urethral stricture and erectile dysfunction, surgical treatment can be reasonable and pay attention to long-term follow-up. This review summarizes the diagnosis and treatment of MGLSc and urethral stricture, in order to improve the diagnosis and treatment of the disease.