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目的 探讨血清中可溶性细胞角蛋白 19片段 (CYFRA2 1-1)和组织多肽抗原 (TPA)联合检测对肺癌的诊断价值。方法 分别采用免疫放射法和酶联免疫法检测 60例首次确诊的肺癌和 3 0例肺良性疾病患者血清中CYFRA2 1-1和TPA水平。结果 肺癌患者血清CYFRA2 1-1、TPA水平均明显高于肺良性疾病 (P <0 0 1) ,其阳性率分别为 48 3 %、61 7% ;二者联合检测的阳性率为 80 %。结论 血清CYFRA2 1-1、TPA联合检测对肺癌有较高的诊断价值
Objective To investigate the diagnostic value of serum cytokeratin 19 (CYFRA2 1-1) and tissue polypeptide antigen (TPA) in the diagnosis of lung cancer. Methods The levels of serum CYFRA21-1 and TPA in 60 patients with first diagnosed lung cancer and 30 patients with benign lung disease were detected by immunoradiometry and enzyme-linked immunosorbent assay respectively. Results The serum levels of CYFRA2 1-1 and TPA in patients with lung cancer were significantly higher than those in patients with benign lung disease (P <0.01). The positive rates of CYFRA2 1-1 and TPA in patients with lung cancer were 48.3% and 61.7%, respectively. Conclusion Serum CYFRA2 1-1, TPA combined detection of lung cancer have a higher diagnostic value