1　前言4 ,5 二甲氧基茚酮是重要药物中间体 ,近期发现也是新型抗老年痴呆药物的中间体 ,该中间体在有机合成中应用广泛。但该化合物的合成、分离、纯化及鉴定方法 ,文献极少报道。本文研究了经五步合成所得样品的分离纯化方法。合成粗品中茚酮含量不足 50 % ,外观类似焦油状物 1 Introduction 4, 5 dimethoxyindan is an important drug intermediate, recently discovered is also a new intermediate for antidementia drugs, the intermediate is widely used in organic synthesis. However, the synthesis, isolation, purification and identification of this compound are rarely reported in the literature. In this paper, the separation and purification of the sample obtained by the five-step synthesis was studied. The synthesis of crude indanone content of less than 50%, the appearance of similar tarry