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目的比较克拉霉素与阿奇霉素治疗鼻咽癌放疗后鼻窦炎的临床效果。方法将医院收治的鼻咽癌放疗后鼻窦炎患者80例作为研究对象,随机分为对照组和观察组,每组40例。2组均给予常规治疗,在常规治疗基础上,对照组采用阿奇霉素进行治疗,观察组采用克拉霉素进行治疗。观察2组患者治疗效果,并比较2组治疗前后CT评分和疼痛评分。结果治疗后,2组总有效率比较差异无统计学意义(P>0.05)。治疗前,2组CT评分、疼痛评分比较差异无统计学意义(P>0.05);治疗后,2组CT评分、疼痛评分较治疗前均降低,且观察组治疗后CT评分、疼痛评分低于对照组(P均<0.05)。结论克拉霉素应用于鼻咽癌放疗后鼻窦炎治疗中可显著降低患者的疼痛感,具有较高临床推广价值。
Objective To compare the clinical effects of clarithromycin and azithromycin in the treatment of nasosinusitis after radiotherapy of nasopharyngeal carcinoma. Methods Eighty patients with nasopharyngeal carcinoma after radiotherapy for nasopharyngeal carcinoma admitted to the hospital were randomly divided into control group and observation group, 40 cases in each group. Both groups were given routine treatment. On the basis of conventional treatment, the control group was treated with azithromycin and the observation group was treated with clarithromycin. The therapeutic effects of the two groups were observed, and the CT scores and pain scores of two groups before and after treatment were compared. Results After treatment, there was no significant difference in the total effective rate between the two groups (P> 0.05). Before treatment, there was no significant difference in CT score and pain score between the two groups (P> 0.05). After treatment, CT score and pain score of both groups were lower than those before treatment, and CT score and pain score of observation group were lower than Control group (all P <0.05). Conclusion The application of clarithromycin in the treatment of nasosinusitis after radiotherapy of nasopharyngeal carcinoma patients can significantly reduce the pain of patients with high clinical value.