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目的：脑康复冲剂临床用于治疗脑血栓血瘀证患者，本实验观察其对在大鼠实验性软脑膜微循环障碍的影响。方法：大鼠预防性给药，用高分子右旋糖酐水溶液静脉注射形成大鼠软脑膜的微循环障碍，观察脑康复冲剂对大鼠微循环的影响。结果：用高分子右旋糖酐造模后，大鼠软脑膜的微循环发生障碍，表现为血液流速减慢、血细胞聚集等，脑康复冲剂组血流速度开始减慢的时间明显比生理盐水对照组延长，且分级数也明显优于生理盐水组，对高分子右旋糖酐造成的血液流态障碍，脑康复组明显好于生理盐水组（P＜0．05），毛细血管网交叉点数开始减少的时间也比生理盐水对照组延长，差异显著（P＜0．01）。结论：脑康复冲剂使大鼠血流速度和血液流态得到改善，具有预防和改善动物脑微循环障碍的作用。
OBJECTIVE: To evaluate the effect of Naofugan Granules on the treatment of cerebral thrombosis and blood stasis syndrome in rats. METHODS: Rats were administered prophylactically, and microcirculatory disturbances of rat pia mater were formed by intravenous injection of polymer dextran aqueous solution. The effect of Nao kang granules on microcirculation of rats was observed. RESULTS: After the model was made with polymer dextran, the microcirculation of rat pia mater was impaired, which was manifested as the decrease of blood flow rate and the accumulation of blood cells. The time for the slowing of blood flow began to be slower in the Brain Rehabilitation Granule group than that in the saline control group. The number of grades was also significantly better than that of the normal saline group. The blood flow impairment caused by polymer dextran was significantly better in the cerebral rehabilitation group than in the saline group (P<0.05), and the time at which the capillary network crossover point started to decrease was also Compared with saline control group, the difference was significant (P<0.01). Conclusion: The brain-recovery granules improve the blood flow velocity and blood flow state of rats, and have the effect of preventing and improving cerebral microcirculatory disturbance in animals.