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目的 :研究 β 内啡肽在幼龄厌食大鼠治疗前后下丘脑的含量变化及其与小儿厌食症的发病关系。方法 :模拟小儿厌食症病因建立幼龄厌食大鼠模型 ,并用运脾方药治疗 ,用免疫组化方法观察正常组、模型组、治疗组下丘脑 β 内啡肽的含量变化 ,结合图像分析技术测定其结果。结果 :模型动物 β 内啡肽低于对照组 (P <0 .0 5) ,儿宝颗粒治疗组下丘脑中 β 内啡肽的含量较模型组显著增高 (P <0 .0 1)。结论 :下丘脑 β 内啡肽的含量降低可能是幼龄厌食大鼠进食量降低的原因之一 ,儿宝颗粒有促进幼龄厌食大鼠下丘脑 β 内啡肽分泌的作用 ,从而增加了摄食量。
Objective: To study the changes of hypothalamus content of β-endorphin in young rats anorexia rats and its relationship with the incidence of anorexia in children. Methods: To establish a model of juvenile anorexia rats by simulating the cause of childhood anorexia. The rats were anaerobically treated with Yunpi Prescription. The content of β-endorphin in the hypothalamus of normal group, model group and treatment group were observed by immunohistochemical method. the result. Results: β-endorphin in model animals was lower than that in control group (P <0.05). The content of β-endorphin in hypothalamus of Erbao Granule-treated group was significantly higher than that of model group (P <0.01). CONCLUSION: The hypothalamic decrease of β-endorphin may be one of the reasons for the decrease of food intake in juvenile anorexia rats. Erbao granule can promote the secretion of β-endorphin in the hypothalamus of juvenile anorexia rats, the amount.