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目的观察并探讨凋亡相关基因Fas/FasL在严重急性呼吸综合征(SARS)病变组织肺、脾、淋巴结中的表达及其在SARS发病中的作用。方法2003年3月至5月,应用免疫组织化学方法对南方医科大学南方医院病理科4例SARS患者尸检组织及正常对照组织(取自非SARS患者尸检个体)肺、脾、淋巴结进行检测。结果与正常组织相比,SARS肺组织肺泡上皮细胞、支气管上皮细胞、巨噬细胞;脾脏及淋巴结淋巴细胞及单核巨噬细胞Fas,FasL表达增强。结论Fas/FasL过度表达在SARS病变组织中普遍存在,提示Fas/FasL介导的凋亡途径在SARS发病过程中可能起一定作用。
Objective To observe and explore the expression of Fas / FasL gene in lung, spleen and lymph node of severe acute respiratory syndrome (SARS) and its role in the pathogenesis of SARS. Methods From March to May 2003, immunohistochemistry was used to detect the lung, spleen and lymph nodes in 4 autopsy tissues of SARS patients and normal control tissues from autopsy individuals without SARS in the Southern Hospital of Southern Medical University. Results Compared with normal tissues, the expression of Fas and FasL in alveolar epithelial cells, bronchial epithelial cells, macrophages, spleen, lymph node lymphocytes and monocyte-macrophages in SARS lung tissue were increased. Conclusion The overexpression of Fas / FasL is common in SARS patients, suggesting that the Fas / FasL-mediated apoptotic pathway may play a role in the pathogenesis of SARS.