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目的研究Ｎ－糖基化抑制对胶质瘤细胞生长状态的影响。方法以依霉素（ｔｕｎｉｃａｍｙｃｉｎ）为Ｎ－糖基化抑制剂，作用于人脑胶质瘤细胞株ＳＷＯ－３８，运用电镜技术及琼脂糖电泳，观察Ｎ－糖基化抑制对胶质瘤细胞生长的影响。结果依霉素作用于ＳＷＯ－３８细胞后，透射电镜下细胞出现线粒体等细胞器增殖，核仁消失，细胞团缩。琼脂糖电泳出现ＤＮＡ梯形条带。结论Ｎ－糖基化抑制可以诱导胶质瘤细胞的早期凋亡。
Objective To investigate the effect of N-glycosylation on the growth of glioma cells. Methods The human glioma cell line SWO-38 was treated with tunicamycin as an inhibitor of N-glycosylation. Electron microscopy and agarose electrophoresis were used to observe the effect of N-glycosylation on glioma cells The impact of growth. The results of the role of mycotoxin in SWO-38 cells, cells under transmission electron microscopy and other mitochondria and other organelles proliferation, disappearance of nucleolus, cell shrinkage. DNA trapezoidal bands appeared on agarose gel electrophoresis. Conclusion N-glycosylation can induce early apoptosis of glioma cells.