目的：研究兰索拉唑三联疗法治疗幽门螺杆菌（Ｈｐ）相关性十二指肠溃疡疗效及安全性，比较１周疗法与２周疗法的Ｈｐ根除率、溃疡愈合率及疼痛缓解率。方法：４６例经胃镜证实的Ｈｐ阳性的十二指肠溃疡患者，随机分成１周疗法组（Ａ组）和２周疗法组（Ｂ组），Ａ组、Ｂ两组用药均为兰索拉唑３０ｍｇ，ｂｉｄ；阿莫西林１．０ｇ，ｂｉｄ；甲硝唑０．４ｇ，ｂｉｄ。Ａ组抗生素（阿莫西林和甲硝唑）只用１周，Ｂ组用２周，兰索拉唑均用２周。停药４周之后复查胃镜观察溃疡愈合、Ｈｐ根除及疼痛缓解情况。结果：溃疡愈合率Ａ组Ｂ两组分别为８５．７％（１８／２１）和９２．０％（２３／２５）；Ｈｐ根除率为７１．４％（１５／２１）和８４％（２１／２５）；３ｄ和７ｄ之内的疼痛缓解率Ａ组分别为７０．６％（１２／１７）和９４．１％（１６／１７）；Ｂ组分别为７１．４％（１５／２１）和９０．５％（１９／２１）；平均疼痛缓解日数Ａ组（３．３±２．４）ｄ；Ｂ组（３．５±２．８）ｄ。Ａ，Ｂ两组之间比较，各项结果均无明显差异（Ｐ＞０．０５）。结论：兰索拉唑三联疗法对根除Ｈｐ及治疗十二指肠溃疡的疗效及安全性１周与２周比较无显著性差异 Objective: To study the efficacy and safety of lansoprazole triple therapy in the treatment of Hp-associated duodenal ulcer, and to compare the Hp eradication rate, ulcer healing rate and pain relief rate in one-week and two-week treatment. Methods: Forty-six patients with Hp-positive duodenal ulcer confirmed by gastroscope were randomly divided into 1 week therapy group (A group) and 2 weeks therapy group (B group). The patients in group A and B were treated with Lansola Azole 30mg, bid; amoxicillin 1.0g, bid; metronidazole 0.4g, bid. Group A antibiotics (amoxicillin and metronidazole) with only 1 week, B group with 2 weeks, lansoprazole are used for 2 weeks. After 4 weeks of treatment, the patients underwent gastroscopy to observe ulcer healing, Hp eradication and pain relief. Results: The rate of ulcer healing was 85.7% (18/21) and 92.0% (23/25) in group A and group B, respectively. The eradication rates of Hp were 71.4% (15/21) and 84% (21% / 25). The rates of pain relief within 3 and 7 days in group A were 70.6% (12/17) and 94.1% (16/17), respectively; those in group B were 71.4% (15/21) And 90.5% (19/21) respectively. The mean pain relief days in group A were (3.3 ± 2.4) days and in group B (3.5 ± 2.8 days) A, B between the two groups, the results were no significant difference (P> 0.05). Conclusions: The efficacy and safety of Lansoprazole triple therapy in eradicating Hp and treating duodenal ulcer have no significant difference between 1 week and 2 weeks