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程序性死亡因子1(PD-1)是免疫球蛋白超家族激活诱导的抑制性受体,它有两个配体:PD-L1和PD-L2。PD-1与其配体PD-L结合后,可调节T细胞的活化及分化,抑制T细胞增殖,发挥对效应T细胞的负性调控作用,参与多种免疫过程,并在动脉硬化、心脏及神经疾病的发生和发展过程中扮演重要角色,因此近年来受到广泛的关注。该文就PD-1/PD-L在动脉硬化、心脏及神经疾病的研究进展予以综述。
Programmed Death Factor 1 (PD-1) is an inhibitory receptor induced by immunoglobulin superfamily activation and has two ligands, PD-L1 and PD-L2. PD-1 binds to its ligand PD-L and regulates the activation and differentiation of T cells, inhibits the proliferation of T cells, plays a negative regulatory role on effector T cells, participates in a variety of immune processes, and atherosclerosis, heart and The occurrence and development of neurological diseases play an important role in recent years, it has received widespread attention. This article reviews the research progress of PD-1 / PD-L in atherosclerosis, cardiac and neurological diseases.